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Product Name: | ML-179 | Synonyms: | ML-179;3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione;2,4(1H,3H)-Pyrimidinedione, 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-;3-cyclohexyl-6-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione;C57Bl6 mice,inhibit,SAA4,ER-negative breast cancer,probe compounds,ML 179,MCF-7,SAA1,Inhibitor,ML179,inverse | CAS: | 1883548-87-5 | MF: | C21H25F3N4O2 | MW: | 422.44 | EINECS: | | Product Categories: | | Mol File: | 1883548-87-5.mol | ![ML-179 Structure](CAS/20181012/GIF/CB23152683.gif) |
| ML-179 Chemical Properties |
density | 1.329±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO: 10 mg/ml | form | A crystalline solid | pka | 9.37±0.40(Predicted) | color | White to off-white | InChI | InChI=1S/C21H25F3N4O2/c22-21(23,24)15-5-4-8-17(13-15)26-9-11-27(12-10-26)18-14-19(29)28(20(30)25-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,25,30) | InChIKey | MFABFKUNLDYKGH-UHFFFAOYSA-N | SMILES | C1(=O)NC(N2CCN(C3=CC=CC(C(F)(F)F)=C3)CC2)=CC(=O)N1C1CCCCC1 |
| ML-179 Usage And Synthesis |
Uses | ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1). It induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells. | storage | Store at +4°C |
| ML-179 Preparation Products And Raw materials |
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