| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:IBTP (iodide)
CAS:159085-21-9
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:IBTP ((4-Iodobutyl)triphenylphosphonium)
CAS:159085-21-9
Purity:98% Package:5mg;10mg;25mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:IBTP (iodide)
CAS:159085-21-9
|
|
| | IBTP ((4-Iodobutyl)triphenylphosphonium) Basic information |
| | IBTP ((4-Iodobutyl)triphenylphosphonium) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 100mM; Ethanol: 50mM | | form | A solid |
| | IBTP ((4-Iodobutyl)triphenylphosphonium) Usage And Synthesis |
| Description | IBTP is a lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner.1 As a result, mitochondrial proteins that have changed thiol redox state following oxidative stress are selectively tagged with IBTP and can be separated by two-dimensional electrophoresis and isolated.1 IBTP-tagged proteins can also be evaluated by immunoblotting using an antibody directed against the triphenylphosphonium moiety of the IBTP molecule.2 IBTP has also been used as a mitochondria-targeted soft electrophile to inhibit mitochondrial oxidative phosphorylation.3 | | References | 1. Lin, T.-K., Hughes, G., Muratovska, A., et al. Specific modification of mitochondrial protein thiols in response to oxidative stress: A proteomics approach J. Biol. Chem. 277(19),17048-17056(2002).
2. Venkatraman, A., Landar, A., Davis, A.J., et al. Oxidative modification of hepatic mitochondria protein thiols: Effect of chronic alcohol consumption Am. J. Physiol. Gastrointest. Liver Physiol. 286(4),G521-G527(2004).
3. Vayalil, P.K., Oh, J.-Y., Zhou, F., et al. A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms PLoS One 10(3),(2015). |
| | IBTP ((4-Iodobutyl)triphenylphosphonium) Preparation Products And Raw materials |
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