Pomalidomide-d5

Pomalidomide-d5 Suppliers list
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 13675144456
Email: sean.lv@synzest.com
Products Intro: Product Name:Pomalidomide-d5
CAS:1377838-49-7
Purity:95%HPLC Package:500mg;1g;5g;10g
Company Name: Changzhou Xianglong Pharmaceutical Technology Co., LTD  
Tel: 18661161657
Email: yaoxiangqiu2021@163.com
Products Intro: Product Name:Pomalidomide-d5
Purity:95% Package:10mg;25mg;50mg;100mg
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:Pomalidomide-d5
CAS:1377838-49-7
Purity:95% Package:500μg;1mg
Company Name: TLC Pharmaceutical Standards Ltd.  
Tel: 18012923235
Email: chinasales04@tlcstandards.com.cn
Products Intro: Product Name:Pomalidomide-d5
CAS:1377838-49-7
Purity:95%+ HPLC Package:10mg;25mg;50mg;100mg
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Email: cayman@caymanchem.com
Products Intro: Product Name:Pomalidomide-d5
CAS:1377838-49-7
Pomalidomide-d5 Basic information
Product Name:Pomalidomide-d5
Synonyms:4-Amino-2-(2,6-dioxopiperidin-3-yl-3,4,4,5,5-d5)isoindoline-1,3-dione;Pomalidomide-d5
CAS:1377838-49-7
MF:C13H11N3O4
MW:273.25
EINECS:
Product Categories:
Mol File:1377838-49-7.mol
Pomalidomide-d5 Structure
Pomalidomide-d5 Chemical Properties
storage temp. Store at -20°C
solubility DMF: 10 mg/ml,DMSO: 15 mg/ml
form A solid
Safety Information
MSDS Information
Pomalidomide-d5 Usage And Synthesis
DescriptionPomalidomide-d5 is intended for use as an internal standard for the quantification of pomalidomide by GC- or LC-MS. Pomalidomide is an analog of thalidomide that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 μM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those expressing a thalidomide-binding defective CRBN mutation. It inhibits proliferation of U266 myeloma cells when used at concentrations ranging from 0.1 to 10 μM. Pomalidomide also has antiangiogenic and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α, and triggering the activation of caspase-8. Pomalidomide (3 mg/kg per day), in combination with dexamethasone, reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model. Formulations containing pomalidomide have been used in the treatment of multiple myeloma.
UsesPomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.
Pomalidomide-d5 Preparation Products And Raw materials
Tag:Pomalidomide-d5(1377838-49-7) Related Product Information
Pomalidomide Impurity 10 Pomalidomide Impurity 17 Pomalidomide Impurity 4 (R)-Pomalidomide Pomalidomide Impurity 10 Pomalidomide Impurity 3 Pomalidomide Impurity 6 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione 5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Pomalidomide (S)-Pomalidomide 3-AMINOPHTHALIC ACID 3,4-Diamino-4-oxobutyric acid 3-Nitrophthalic acid 2-(2,6-dioxopiperidin-3-yl)-4-(hydroxyamino)isoindoline-1,3-dione Pomalidomide Impurity 2 4-Hydroxy ThalidoMide DL-Glutamine