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2'2'-cGAMP

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Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:2’2’-cGAMP
CAS:1465774-27-9
Purity: 98% by HPLC Remarks:BOC Sciences also provides custom synthesis services for 2’2’-cGAMP.
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:2',2'-cGAMP
CAS:1465774-27-9
Purity:> 95% Remarks:https://www.bocsci.com/2-2-cgamp-item-472177.html
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:2’2’-cGAMP
CAS:1465774-27-9
Purity:98% Package:500μg;1mg
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774
Email: sales@glpbio.cn
Products Intro: Product Name:2’2’-cGAMP (sodium salt)
CAS:1465774-27-9
Purity:>98% Package:1mg;10mg;50mg;100mg;
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:2’2’-cGAMP sodium salt
CAS:1465774-27-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
2'2'-cGAMP Basic information
Product Name:2'2'-cGAMP
Synonyms:2'2'-cGAMP;2’2’-cGAMP (sodium salt);2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt;2'2'-cGAMP (sodium salt)
CAS:1465774-27-9
MF:C20H24N10O13P2
MW:674.411
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Mol File:1465774-27-9.mol
2'2'-cGAMP Structure
2'2'-cGAMP Chemical Properties
Boiling point 1159.9±75.0 °C(Predicted)
density 2.61±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Water: soluble
form A crystalline solid
pka0.88±0.70(Predicted)
Safety Information
MSDS Information
2'2'-cGAMP Usage And Synthesis
Description2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).
2'2'-cGAMP Preparation Products And Raw materials
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