FW1256
| 中文名称 | FW1256 |
|---|---|
| 中文同义词 | 化合物 T15361 |
| 英文名称 | FW1256 |
| 英文同义词 | FW1256;1,3,2-Benzoxazaphosphole, 2,3-dihydro-2-phenyl-, 2-sulfide;FW1256,FW-1256 |
| CAS号 | 117089-08-4 |
| 分子式 | C12H10NOPS |
| 分子量 | 247.25 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 117089-08-4.mol |
| 结构式 |  |
FW1256 性质
| 熔点 | 139-142 °C |
|---|---|
| 沸点 | 376.3±25.0 °C(Predicted) |
| 密度 | 1.37±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥250mg/mL（1011.12mM） |
| 酸度系数(pKa) | -0.88±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
FW1256 (200 µM; 24.5 hours; AW264.7 cells) treatment significantly reduces IL-1β, COX-2 and iNOS mRNA and protein in LPS-stimulated RAW264.7 macrophages.
FW1256 (200 µM; 24.5 hours; AW264.7 cells) treatment significantly reduces IL-1β, COX-2 and iNOS PROTE and protein in LPS-stimulated RAW264.7 macrophages.
FW1256 concentration dependently decreases TNF-α (IC
50
of 61.2 µM), IL-6 (IC
50
of 11.7 µM), PGE2 (IC
50
of 25.5 µM) and NO (IC
50
of 34.6 µM) generation in LPS-stimulated RAW264.7 macrophages and bone marrow-derived macrophages (BMDMs) (IC
50
s of 414.9 µM, 300.2 µM, 4 µM and 9.5 µM for TNF-α, IL-6, PGE2 and NO, respectively) .
FW1256 decreases NF-κB activation as evidenced by reduced cytosolic phospho-IκBα levels and reduces nuclear p65 levels in LPS-stimulated RAW264.7 macrophages treated with FW1256.
RT-PCR
| Cell Line: | RAW264.7 cells |
| Concentration: | 200 µM |
| Incubation Time: | 24.5 hours |
| Result: | Significantly reduced IL-1β, COX-2 and iNOS mRNA in LPS-stimulated RAW264.7 macrophages.. |
Western Blot Analysis
| Cell Line: | RAW264.7 cells |
| Concentration: | 200 µM |
| Incubation Time: | 24.5 hours |
| Result: | Significantly reduced IL-1β, COX-2 and iNOS proteinin LPS-stimulated RAW264.7 macrophages.. |
FW1256 (100 mg/kg; intraperitoneal injection; male C57BL/6 mice) treatment reduces IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice.
| Animal Model: | Male C57BL/6 mice (20-25 g, 6-10 weeks) injected with E. coli lipopolysaccharide (LPS) |
| Dosage: | 100 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Reduced IL-1β, TNFα, nitrate/nitrite and PGE2 levels in LPS-treated mice. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-121955 | FW1256 | 1 mg | 1280元 | |
| 2024/11/08 | HY-121955 | FW1256 FW1256 | 117089-08-4 | 5mg | 3200元 |