COX-2-IN-1
中文名称 | COX-2-IN-1 |
---|---|
中文同义词 | 化合物 T10033;化合物COX-2-IN-1 |
英文名称 | 1-(4-Sulfamylphenyl)-3-trifluoromethyl-5-(7-chloroindol-3-yl)-2-pyrazoline |
英文同义词 | 1-(4-Sulfamylphenyl)-3-trifluoromethyl-5-(7-chloroindol-3-yl)-2-pyrazoline;4-(5-(7-chloro-1H-indol-3-yl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide;COX-2-IN-1;Benzenesulfonamide, 4-[5-(7-chloro-1H-indol-3-yl)-4,5-dihydro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-;COX 2 IN 1,COX2IN1 |
CAS号 | 787623-48-7 |
分子式 | C18H14ClF3N4O2S |
分子量 | 442.8425696 |
EINECS号 | |
相关类别 | |
Mol文件 | 787623-48-7.mol |
结构式 |
COX-2-IN-1 性质
储存条件 | Store at -20°C |
---|---|
溶解度 | 溶于二甲基亚砜 |
COX-2 3.9 μM (IC 50 ) |
COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC 50 s of >100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound.