N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea
中文名称 | N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea |
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中文同义词 | 化合物T12156;1-(2-氯-6-甲基苯基)-3-(吡啶-4-基)脲 |
英文名称 | N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea |
英文同义词 | Urea, N-(2-chloro-6-methylphenyl)-N'-4-pyridinyl-;N(2Chloro6methylphenyl)N'4pyridinylurea,inhibit,N (2 Chloro 6 methylphenyl) N' 4 pyridinylurea,Inhibitor;N-(2-Chloro-6-methylphenyl)-N''-4-pyridinylurea |
CAS号 | 97627-24-2 |
分子式 | C13H12ClN3O |
分子量 | 261.71 |
EINECS号 | |
相关类别 | |
Mol文件 | 97627-24-2.mol |
结构式 | ![]() |
N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea 性质
储存条件 | Store at -20°C |
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溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
颜色 | 白色至米白色 |
Compound shows anticonvulsant activity at 30 mg/kg in the initial tests with no signs of ataxia until 300 mg/kg. The activity seen with 30 mg/kg 37 is still present 4 h postdose. Compound is effective against seizures induced by maximal electroshock but does not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacological profile suggests that Compound would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. Compound is selected for clinical trials.