191592-09-3
| 中文名称 | 191592-09-3 |
|---|---|
| 中文同义词 | 化合物 T12597;5-HT2拮抗剂1 |
| 英文名称 | Pyrrolo[3,2-c]azepin-4(1H)-one, 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-5,6,7,8-tetrahydro-8-hydroxy-1-methyl- |
| 英文同义词 | Pyrrolo[3,2-c]azepin-4(1H)-one, 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-5,6,7,8-tetrahydro-8-hydroxy-1-methyl-;5-HT2 antagonist 1;5HT2 antagonist 1,5 HT2 antagonist 1,5-HT-2 antagonist 1 |
| CAS号 | 191592-09-3 |
| 分子式 | C22H29FN4O2 |
| 分子量 | 400.49 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 191592-09-3.mol |
| 结构式 |  |
191592-09-3 性质
| 沸点 | 613.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.28±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 14.38±0.20(Predicted) |
5-HT2 antagonist 1 是一种有效的 5-HT2 receptor 拮抗剂，同时对 α1 adrenoceptor 有微弱地抑制作用。
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5-HT 2 Receptor
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α1
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5-HT2 antagonist 1 shows 45%, 88%, 93% inhibition of 10 μM erotonin-induced contraction at 10 nM, 100 nM, 1000 nM, respectively, in guinea pig mesentcric artery. 5-HT2 antagonist 1 causes 1% and 10% inhibition of 10 μM norepinephrine-induced contraction at 10 and 100 nM, respectively, in guinea pig aorta.