Log in | Join Free | china | japan | germany

ML 204

Request For Quotation
ML 204 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:ML204
CAS:2070015-10-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:ML204 hydrochloride；ML204;ML204 HCl;ML-204
CAS:2070015-10-8
Package:1 g；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:ML204 HCl
CAS:2070015-10-8
Purity:98% Package:5mg Remarks:V4005
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Products Intro: Product Name:ML204 hydrochloride
CAS:2070015-10-8
Package:2mg;49USD
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: 021-QQ：65489617 15618227136
Email: Sales@ATKchemical.com
Products Intro: Product Name:ML204
CAS:2070015-10-8
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G

ML 204 manufacturers

  • ML204 hydrochloride
  • ML204 hydrochloride pictures
  • $49.00 / 2mg
  • 2024-10-24
  • CAS:2070015-10-8
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
ML 204 Basic information
Product Name:ML 204
Synonyms:ML204 hydrochloride,ML-204 hydrochloride;4-Methyl-2-(piperidin-1-yl)quinoline hydrochloride
CAS:2070015-10-8
MF:C15H19ClN2
MW:262.78
EINECS:
Product Categories:
Mol File:2070015-10-8.mol
ML 204 Structure
ML 204 Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form Solid
color White to off-white
Safety Information
MSDS Information
ML 204 Usage And Synthesis
Biological ActivityML204 is a potent and selective inhibitor of TRPC4/TRPC5 channels with 20-fold selectivity over TRPC6, without affecting other TRP channels and voltage-gated sodium, potassium or Ca2+ channels.
in vitro

ML204 inhibits TRPC4β-mediated intracellular Ca 2+ rise with an IC 50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation.
It blocks TRPC4β activity induced through either G i/o stimulation by μ-opioid, 5HT 1A serotonin, and M 2 muscarinic receptors or G q/11 stimulation by the endogenous M 3 -like muscarinic receptors.
It blocks LPS-induced TRPC5 channel activity.

in vivo

ML204 (1 mg/kg; sc; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice.

< td class="col2"> Subcutaneous injection, twice a day, for 5 days (prior to LPS injection) < td class="col2"> Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
Animal Model: Nonfasted male C57BL/6 (2-3 months)
Dosage: 1 mg/kg
Administration:
Result:
target

TRPC4

TRPC5

ML 204 Preparation Products And Raw materials
Tag:ML 204(2070015-10-8) Related Product Information
ML346 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264