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| | ANTI-CHROMOBOX PROTEIN HOMOLOG 1 Basic information |
| Product Name: | ANTI-CHROMOBOX PROTEIN HOMOLOG 1 | | Synonyms: | ANTI-CHROMOBOX PROTEIN HOMOLOG 1;ANTI-P25BETA;ANTI-MODIFIER PROTEIN M31;ANTI-HP1-BETA;ANTI-HP1HSBETA;ANTI-HETEROCHROMATIN PROTEIN 1 HOMOLOG BETA;ANTI-HETEROCHROMATIN PROTEIN P25;Anti-Chromobox Protein Homolog 1, Anti-Heterochromatin Protein 1 Homolog β, Anti-Heterochromatin Protein p25, Anti-HP1Hsβ, Anti-Modifier Protein M31, Anti-p25β | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-CHROMOBOX PROTEIN HOMOLOG 1 Structure]() |
| | ANTI-CHROMOBOX PROTEIN HOMOLOG 1 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | ANTI-CHROMOBOX PROTEIN HOMOLOG 1 Usage And Synthesis |
| General Description | The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer′s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer′s disease. (provided by RefSeq) |
| | ANTI-CHROMOBOX PROTEIN HOMOLOG 1 Preparation Products And Raw materials |
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