Log in | Join Free | china | japan | germany

3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole

Request For Quotation
3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Suppliers list
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Email: market18@leapchem.com
Products Intro: Product Name:FSEN1
CAS:862808-01-3
Purity:0 Package:1g; 5g; 25g; 1kg; 5kg; 25kg Remarks:0
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ:65489617 15618227136
Email: info@SuperLan-chem.com
Products Intro: Product Name:FSEN1
CAS:862808-01-3
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
Company Name: Suzhou Chenrui Biotechnology Co. LTD  
Tel: 17625585511
Email: 1580084073@qq.com
Products Intro: Product Name:FSEN1
CAS:862808-01-3
Purity:98% Package:1g;5g;10g
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:FSEN1
CAS:862808-01-3
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g+，10mg，more
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:FSEN1；
CAS:862808-01-3
Purity:98.56% Package:详见官网
3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Basic information
Product Name:3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole
Synonyms:3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole;FSEN1;Thiazolo[2,3-c]-1,2,4-triazole, 3-(4-bromophenyl)-6-[[4-(4-methoxyphenyl)-1-piperazinyl]methyl]-;1-{[3-(4-bromophenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-6-yl]methyl}-4-(4-methoxyphenyl)piperazine
CAS:862808-01-3
MF:C22H22BrN5OS
MW:484.41
EINECS:
Product Categories:
Mol File:862808-01-3.mol
3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Structure
3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Chemical Properties
density 1.52±0.1 g/cm3(Predicted)
solubility DMF: 1 mg/ml; DMSO: Slightly soluble
form A crystalline solid
pka6.56±0.10(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Usage And Synthesis
DescriptionFSEN1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1; IC50 = 313 nM).1 It is selective for FSP1 over NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1; IC50 = >100 μM). FSEN1 induces cell death in GPX4-/- H460 non-small cell lung cancer (NSCLC) cells (EC50 = 69.36 nM) but not control H460 cells expressing Cas9 (H460Cas9). It sensitizes A549, Huh7, HCC1143, U2OS, SU-DHL-5, and T98G cancer cells to ferroptosis induced by (1S,3R)-RSL3 when used at concentrations ranging from 10 to 1,000 nM. FSEN1 also sensitizes H460Cas9 cells, but not FSP1-/- H460 cells, to cell death induced by the ferroptosis inhibitors dihydroartemisinin or FINO2 .
References1. Hendricks, J.M., Doubravsky, C., Wehri, E., et al. Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis bioRxiv ,(2022).
3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole Preparation Products And Raw materials
Tag:3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole(862808-01-3) Related Product Information