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| Product Name: | C188-9 | | Synonyms: | C188-9;C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084;N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide;C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084;F0808-0084;Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;TTI-101 | | CAS: | 432001-19-9 | | MF: | C27H21NO5S | | MW: | 471.52 | | EINECS: | | | Product Categories: | | | Mol File: | 432001-19-9.mol |  |
| | C188-9 Chemical Properties |
| Boiling point | 680.9±65.0 °C(Predicted) | | density | 1.416±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml | | form | A crystalline solid | | pka | 8.14±0.50(Predicted) | | color | Off-white to pink |
| | C188-9 Usage And Synthesis |
| Biological Activity | C188-9 (TTI 101) is a potent STAT3 inhibitor, binds STAT3 with high affinity, Kd=4.7±0.4 nM. It is well tolerated in mice, has good oral bioavailability, and is mainly enriched in tumor tissues. | | in vitro | C188-9 is a small molecule inhibitor of STAT3, targeting the phosphotyrosine peptide binding site in the SH2 region of STAT3 with a Ki value of 136 nM. It does not inhibit upstream Jak or Src kinases. | | in vivo | C188-9 inhibited tumor growth in mice bearing UM-SCC-17B xenografts after administration of C188-9. C188-9 was well tolerated in mice, had good oral bioavailability, and was concentrated in tumor tissue after administration. | | target | | Target | Value | STAT3
(Cell-free) | 4.7 nM(Kd) |
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| | C188-9 Preparation Products And Raw materials |
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