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| | DM3-Sme Basic information |
| Product Name: | DM3-Sme | | Synonyms: | DM3-Sme;Maytansine, N2'-deacetyl-N2'-[4-(methyldithio)-1-oxopentyl]- (9CI) | | CAS: | 796073-70-6 | | MF: | C38H54ClN3O10S2 | | MW: | 812.43 | | EINECS: | | | Product Categories: | | | Mol File: | 796073-70-6.mol |  |
| | DM3-Sme Chemical Properties |
| Boiling point | 962.6±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.82±0.70(Predicted) |
| | DM3-Sme Usage And Synthesis |
| Description | DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2]. | | Uses | DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2]. | | IC 50 | Maytansinoids | | References | [1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).
[2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-Science. |
| | DM3-Sme Preparation Products And Raw materials |
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