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DM3-Sme

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DM3-Sme Suppliers list
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:DM3-SMe
CAS:796073-70-6
Purity:>=98% Package:5mg Remarks:BOC Sciences also provides custom synthesis services for DM3-SMe.
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:DM3-SMe
CAS:796073-70-6
Purity:98.00% Package:100 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai Hao Zhun Biological Technology Co., Ltd.  
Tel: 15800340161
Email: info@zzsrm.com
Products Intro: Product Name:DM3-SMe
CAS:796073-70-6
Purity:.95
DM3-Sme Basic information
Product Name:DM3-Sme
Synonyms:DM3-Sme;Maytansine, N2'-deacetyl-N2'-[4-(methyldithio)-1-oxopentyl]- (9CI)
CAS:796073-70-6
MF:C38H54ClN3O10S2
MW:812.43
EINECS:
Product Categories:
Mol File:796073-70-6.mol
DM3-Sme Structure
DM3-Sme Chemical Properties
Boiling point 962.6±65.0 °C(Predicted)
density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka9.82±0.70(Predicted)
Safety Information
MSDS Information
DM3-Sme Usage And Synthesis
Description

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

References

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.

DM3-Sme Preparation Products And Raw materials
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