| Company Name: |
United States Biological
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| Tel: |
1-800-520-3011 |
| Email: |
sales@advtechind.com |
| Products Intro: |
Product Name:GRF-1
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| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:affinity isolated antibody Remarks:clone 3D8, purified immunoglobulin, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| Company Name: |
BD Biosciences
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| Tel: |
1 877 232 8995 U.S. orders |
| Email: |
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| Products Intro: |
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| | ANTI-SOS1 Basic information |
| | ANTI-SOS1 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| Hazard Codes | Xn | | Risk Statements | 21/22 | | Safety Statements | 36/37 | | WGK Germany | - |
| | ANTI-SOS1 Usage And Synthesis |
| Uses | Detection of Sos-1 by immunoblotting is possible by using a minimum antibody working dilution of 1:4,000 in whole extracts of A431 (human epidermoid carcinoma) and PC 12 (rat pheochromocytoma) cell lines. For indirect immunofluorescent staining a minimum working dilution of 1:500 may be used in cultured canine MDCK cells. The antibody is suitable for protein microarray. | | General Description | Son of Sevenless (SOS) was first discovered in Drosophila, responsible for normal eye development. Two homologs in mouse and humans have been described, Sos-1 and Sos-2; mouse Sos-1 and Sos-2 are 70% identical. Mammalian Sos proteins are present in the inner cell membrane. Sos-1 is a dual guanine nucleotide exchange factor that activates Rac1 and Ras in response to growth factors. Sos-1 can associate also with the GRAP adaptor protein and it is also capable of forming complexes that exhibit Rac-specific guanine nucleotide exchange factor activity. Along with receptor tyrosine kinases, Sos-1 plays an important role in cellular migration and proliferation. In plants, Sos-1 is important to maintain salt concentration across the cell membranes.
Anti-Sos-1 specifically recognizes Sos-1 by immunoblotting (170 kDa). An additional band of lower molecular weight may be detected in some cell line extracts. |
| | ANTI-SOS1 Preparation Products And Raw materials |
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