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| | YAP-TEAD Inhibitor 1 Basic information |
| Product Name: | YAP-TEAD Inhibitor 1 | | Synonyms: | YAP-TEAD Inhibitor 1;YAP-TEAD-IN-1;L-α-Glutamine, N-acetyl-L-valyl-L-prolyl-3-chloro-L-phenylalanyl-L-homocysteinyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-prolyl-L-alanyl-L-seryl-L-phenylalanyl-L-cysteinyl-L-lysyl-L-prolyl-L-prolyl-, cyclic (4→13)-disulfide;Y413924] YAP-TEAD | | CAS: | 1659305-78-8 | | MF: | C93H144ClN23O21S2 | | MW: | 2019.86 | | EINECS: | | | Product Categories: | | | Mol File: | 1659305-78-8.mol |  |
| | YAP-TEAD Inhibitor 1 Chemical Properties |
| density | 1.45±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 4.45±0.10(Predicted) | | Water Solubility | Water: 40 mg/mL (19.80 mM); |
| | YAP-TEAD Inhibitor 1 Usage And Synthesis |
| Biological Activity | YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM.
The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2]. | | References | [1] Zhang Z, et al. ACS Med Chem Lett. 2014, 5(9):993-998.
[2] Zhou Z, et al. FASEB J. 2015, 29(2):724-732. |
| | YAP-TEAD Inhibitor 1 Preparation Products And Raw materials |
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