METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE
生物活性靶点体外研究体内研究 用途与合成方法 MSDS METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE价格(试剂级) 上下游产品信息
| 中文名称 | METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE |
|---|---|
| 中文同义词 | 化合物R-10015;2-(1-(5-氯-7H-吡咯并[2,3-D]嘧啶-4-基)哌啶-4-基)-1H-苯并[D]咪唑-6-羧酸甲酯 |
| 英文名称 | 1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester |
| 英文同义词 | 1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester;Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxylate;methyl 2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate;Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate;R-10015,inhibit,R10015,Inhibitor,LIMKs,Reverse Transcriptase,LIM Kinase (LIMK),R 10015 |
| CAS号 | 2097938-51-5 |
| 分子式 | C20H19ClN6O2 |
| 分子量 | 410.86 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2097938-51-5.mol |
| 结构式 | ![METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 结构式](CAS/20200331/GIF/2097938-51-5.gif) |
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 性质
| 密度 | 1.465±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：62.5 mg/mL（152.12 mM；需要超声波） |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.68±0.10(Predicted) |
| 颜色 | 米白色至粉红色 |
METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE 用途与合成方法
R-10015 是一种有效的、具有选择性的 LIM domain kinase (LIMK) 抑制剂，对于人LIMK1的IC50值为38 nM。R-10015 会结合到 ATP-binding pocket 上，并充当HIV感染的广谱抗病毒化合物。
| Target | Value |
|
hLIMK1
(Cell-free assay) | 38 nM |
R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.
R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release.
R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) .
Western Blot Analysis
| Cell Line: | CEM-SS T cells |
| Concentration: | 100 μM |
| Incubation Time: | 0 hour,0.5 hour,1 hour,2 hours,4 hours |
| Result: | Inhibited cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells. |
R-10015 (10 mg/kg; i.p.) displays none indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections.
| Animal Model: | 6-8 weeks female C3H/HeN mice |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Displayed none indication of toxicity. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | S6837 | METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE R-10015 | 2097938-51-5 | 2mg | 1870.64元 |
| 2024/01/16 | S6837 | METHYL 2-(1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-YL)-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE R-10015 | 2097938-51-5 | 5mg | 3700.86元 |