| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:AD57 (hydrochloride)
CAS:2320261-72-9
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
Shanghai Dongyang Biotechnology Co., Ltd.
|
| Tel: |
0512-0512-13601744364 13601744364 |
| Email: |
chemsharker@126.com |
| Products Intro: |
Product Name:AD57 (hydrochloride)
CAS:2320261-72-9
Purity:98% Package:1g 5g 10g 25g 50g 100g
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:AD57 hydrochloride
CAS:2320261-72-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:AD57 (hydrochloride)
CAS:2320261-72-9
Purity:0 Package:1mg/RMB 1080;10mg/RMB 8340;5mg/RMB 4720
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| Company Name: |
Nanjing Tengyi Biotechnology Co., Ltd
|
| Tel: |
025-58851786 17714337195 |
| Email: |
sales@tybiochem.com |
| Products Intro: |
Product Name:AD57 (hydrochloride)
CAS:2320261-72-9
Purity:95+% Package:1g;5g
|
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| | AD57 (hydrochloride) Basic information |
| Product Name: | AD57 (hydrochloride) | | Synonyms: | AD57 (hydrochloride);N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea,monohydrochloride | | CAS: | 2320261-72-9 | | MF: | C22H21ClF3N7O | | MW: | 491.8966496 | | EINECS: | | | Product Categories: | | | Mol File: | 2320261-72-9.mol |  |
| | AD57 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 14 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid |
| | AD57 (hydrochloride) Usage And Synthesis |
| Description | Complex diseases, like cancer, may best be countered by compounds that affect multiple targets. AD57 is a polypharmacological cancer therapeutic, in that it is designed to modulate multiple targets related to cancer.1 In Drosophila, it potently inhibits the receptor tyrosine kinase RET (IC50 = 2 nM) and reduces the activity of numerous other kinases by more than 80% when given at 1 μM.1 Most notably, AD57 interferes with kinases downstream of RET, including Src, Raf, and S6K, providing further efficacy in preventing signaling leading to invasion, proliferation, and metabolism relevant to cancer.1 | | References | 1. Dar, A.C., Das, T.K., Shokat, K.M., et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology Nature 486,80-84(2012). |
| | AD57 (hydrochloride) Preparation Products And Raw materials |
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