Company Name: |
InvivoChem
|
Tel: |
13549236410 |
Email: |
sales@invivochem.cn |
Products Intro: |
Product Name:LTβR-IN-1 CAS:2189366-77-4 Purity:98% HPLC Package:1mg Remarks:V31576
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Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
|
Tel: |
0512-65118909 15162312715 |
Email: |
sales@szzxbio.com |
Products Intro: |
Product Name:LTβR-IN-1 CAS:2189366-77-4 Purity:98%+ Package:1g;10g;100g
|
Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
Tel: |
021-65675885 18964387627 |
Email: |
customer_service@efebio.com |
Products Intro: |
Product Name:LTβR-IN-1 CAS:2189366-77-4 Purity:99% Package:1mg;5mg;10mg
|
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| Compound 919278 Basic information |
Product Name: | Compound 919278 | Synonyms: | Compound 919278;LTβR-IN-1;LTβR-IN-1;LTβR IN 1,LTβRIN1;2H-Isoindole-2-acetamide, N-1H-benzimidazol-2-yl-1,3-dihydro-α-methyl-1-oxo-, (αR)- | CAS: | 2189366-77-4 | MF: | C18H16N4O2 | MW: | 320.35 | EINECS: | | Product Categories: | | Mol File: | 2189366-77-4.mol | |
| Compound 919278 Chemical Properties |
density | 1.424±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 125 mg/mL (390.20 mM; Need ultrasonic) | form | Solid | pka | 10.68±0.10(Predicted) | color | White to off-white |
| Compound 919278 Usage And Synthesis |
Biological Activity | LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α-induced p65 nuclear translocation[1]. | References | [1]. Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11(541). |
| Compound 919278 Preparation Products And Raw materials |
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