| Company Name: |
ChemShuttle, Inc.
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| Tel: |
0510-83588313-802 18800520310; |
| Email: |
sales@chemshuttle.com |
| Products Intro: |
Product Name:1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea
CAS:790663-33-1
Purity:95% Package:5mg;25mg;100mg;500mg;1g;5g;10g;25g;50g;100g;250g;500g;kg…
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| | PBD-150 Basic information |
| Product Name: | PBD-150 | | Synonyms: | PBD-150;1-(3-(1H-imidazol-1-yl)propyl)-3-(3,4-dimethoxyphenyl)thiourea;Inhibitor,Amyloid-β,PBD150,Abeta,PBD-150,β-amyloid peptide,inhibit,PBD 150,Alzheimer;Thiourea, N-(3,4-dimethoxyphenyl)-N'-[3-(1H-imidazol-1-yl)propyl]- | | CAS: | 790663-33-1 | | MF: | C15H20N4O2S | | MW: | 320.41 | | EINECS: | | | Product Categories: | | | Mol File: | 790663-33-1.mol |  |
| | PBD-150 Chemical Properties |
| Melting point | 160.0-161.0 °C(Solv: ethanol (64-17-5)) | | Boiling point | 502.7±60.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml) | | form | solid | | pka | 12.29±0.70(Predicted) | | color | White | | Stability: | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| | PBD-150 Usage And Synthesis |
| Description | PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.2 | | References | Buchholz et al. (2006), The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship; J. Med. Chem., 49 664
Schilling et al. (2008), Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer’s disease-like pathology; Nat. Med., 14 1106 |
| | PBD-150 Preparation Products And Raw materials |
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