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| | T-3775440 hydrochloride Basic information |
| Product Name: | T-3775440 hydrochloride | | Synonyms: | T-3775440HCl;T-3775440 hydrochloride;T 3775440;T3775440;T3775440 hydrochloride,T-3775440,inhibit,T3775440,T 3775440,Inhibitor,T 3775440 hydrochloride,Histone Demethylase | | CAS: | 1422535-52-1 | | MF: | C18H23ClN4O | | MW: | 346.86 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 1422535-52-1.mol |  |
| | T-3775440 hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : ≥ 30.18 mg/mL (87.01 mM) | | form | Solid | | color | Light yellow to yellow |
| | T-3775440 hydrochloride Usage And Synthesis |
| Biological Activity | | Target | Value | LSD1
() | 2.1 nM |
| | Biological Activity | T-3775440 hydrochloride is an irreversible LSD1 inhibitor. It is highly selective for LSD1 relative to other monoamine oxidases with IC50 of 2.1 nM. | | in vitro | T-3775440 hydrochloride enhances the transdifferentiation of erythrocytes/megakaryocytes to granule-like monocytes. It disrupts the interaction of LSD1 and GFI1B. AEL (TF-1a, HEL92.1.7) cells and AMKL (CMK11-5, M07e) cells were treated with T-3775440 for 48 hours, which induced cell cycle arrest and apoptosis. In TF-1a and CMK11-5 cells, treatment with T-3775440 increased cells in G1 and sub-G1 phases. | | in vivo | T-3775440 inhibits tumor growth in a mouse xenograft model of AML. In mice T-3775440 hydrochloride caused a transient decrease in platelets followed by a large rebound. After a single dose, it had no apparent effect on red blood cell counts. T-3775440 hydrochloride also exerted antitumor activity in AEL (HEL 92.1.7) model and AMKL (CMK11-5) model. |
| | T-3775440 hydrochloride Preparation Products And Raw materials |
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