| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:Anti-SMA antibody, Rabbit monoclonal
Purity:clone SP171, recombinant, expressed in proprietary host, aff Package:100UL Remarks:SAB5500002-100UL
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| | Anti-SMA antibody, Rabbit monoclonal Basic information |
| | Anti-SMA antibody, Rabbit monoclonal Chemical Properties |
| | Anti-SMA antibody, Rabbit monoclonal Usage And Synthesis |
| Uses | Anti-SMA antibody, Rabbit monoclonal has been used in:
- western blotting
- immunohistochemistry
- immunofluorescence
| | General Description | Smooth muscle actin-α (SMA), also known as α2-smooth muscle actin (ACTA2), is a cytoskeleton protein in smooth muscle cells. It is encoded by the gene mapped to human chromosome 10q23.31. SMA is a vascular smooth muscle specific isoform, | | Biochem/physiol Actions | Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and facilitates vascular smooth muscle cell contraction. The encoded protein regulates c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) expression in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Thus, SMA can be used as a potential prognostic biomarker and/or target for treating metastatic lung adenocarcinoma. Mutation in the gene is associated with the development of patent ductus arteriosus (PDA), bicuspid aortic valve (BAV), iris flocculi, livedo reticularis, cerebrovascular accident (CVA) and stenosis of the aortic vasa vasorum. In addition, variation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD). |
| | Anti-SMA antibody, Rabbit monoclonal Preparation Products And Raw materials |
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