| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Human Cathepsin D ELISA
Purity:for serum, plasma and cell culture supernatants Package:1KT Remarks:RAB1317-1KT
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Products Intro: |
Product Name:Human Cathepsin D ELISA
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| | Human Cathepsin D ELISA Basic information |
| | Human Cathepsin D ELISA Chemical Properties |
| | Human Cathepsin D ELISA Usage And Synthesis |
| Uses | For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details. | | General Description | This ELISA antibody pair detects human Cathepsin D. Other species not yet determined. | | Biochem/physiol Actions | Cathepsin D encoded by CTSD gene, is an aspartyl protease, plays a major role in degradation of intracellular and endocytosed protein, for maintenance of tissue homeostasis and metabolism. Cathepsin D works as an endopeptidase in the acidic environment of lysosomes. Cathepsin D is part of signal transduction and a potential target for various cancer. Increased levels of Cathepsin D is associated with type 2 diabetes. Cathepsin D regulates sphingolipid metabolism and cholesterol trafficking. Genetic variations in Cathepsin D gene is a risk factor for Alzheimer′s disease and neuronal ceroid lipofuscinosis. Cathepsin D is a key marker in atherosclerosis and level of expression is increased in atherosclerotic lesions. Cathepsin D regulates the degradation of advanced glycation end products (AGEs) and impaired activity of cathepsin D results in accumulation of AGEs in photoaged skin. Increased plasma concentration of Cathepsin D causes non-alcoholic steatohepatitis (NASH) leading to hepatic lipid accumulation and inflammation. |
| | Human Cathepsin D ELISA Preparation Products And Raw materials |
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