CPI-455 Hydrochloride

CPI-455 Hydrochloride Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:CPI-455 HCl
CAS:2095432-28-1
Package:25 mg;5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:CPI-455hydrochloride
CAS:2095432-28-1
Purity:98%+ Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Tel: +86-18341751992 +86-15382112998
Email: 757984502@qq.com
Products Intro: Product Name:CPI-455 Hydrochloride
CAS:2095432-28-1
Purity:0.98 Package:100mg;500mg;1g;5g Remarks:existing product
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:CPI-455 HCl
CAS:2095432-28-1
Purity:99% Package:$365.9/5mg;$477.9/10mg;$1207.9/25mg;$1785.9/50mg;$3213.9/100mg;Bulk package Remarks:99%
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Email: sales@amadischem.com
Products Intro: Product Name:CPI-455 hydrochloride
CAS:2095432-28-1
Purity:0.97 Package:mgs,gs,kgs Remarks:A919360
CPI-455 Hydrochloride Basic information
Product Name:CPI-455 Hydrochloride
Synonyms:CPI-455 Hydrochloride;6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile hydrochloride;CPI455 HCl,CPI 455 HCl
CAS:2095432-28-1
MF:C16H15ClN4O
MW:314.77
EINECS:
Product Categories:
Mol File:2095432-28-1.mol
CPI-455 Hydrochloride Structure
CPI-455 Hydrochloride Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility ≥31.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
Water Solubility Water: Insoluble
Safety Information
MSDS Information
CPI-455 Hydrochloride Usage And Synthesis
Biological Activitycpi-455 is a kdm5 inhibitor.the kdm5 family of histone demethylases catalyzes the demethylation of histone h3 on lysine 4 (h3k4) and is required for the survival of drug-tolerant persister cancer cells (dtps).
in vitroprevious study found that cpi-455 could potently inhibit the fulllength kdm5a in enzymatic assays with a half-maximal inhibitory concentration of 10 ± 1 nm. cpi-455 inhibited kdm5a, kdm5b and kdm5c to similar levels but showed significantly weaker potency toward kdm4c and kdm7b (~200- and 770-fold, respectively) and no detectable inhibition of kdm2b, kdm3b or kdm6a. moreover, it was found that the cpi-455-mediated kdm5 inhibition led to a dose-dependent increase in global h3k4me3 in hela cells, and the removal of cpi-455 resulted in a rapid reversal of h3k4me3 increases in hela cells. moreover, cpi-455 could delay the appearance of heavy h3k4me3, which was consistent with the role for kdm5 enzymes in h3k4me3 turnover, however, the turnover of h3k4me2 was only marginally altered. as expected, cpi-455 could affect the turnover of h3k4 monomethylation [1].
target
TargetValue
KDM5A
(Cell-free assay)
10 nM
IC 5010 nm
references[1] vinogradova m, et al. an inhibitor of kdm5 demethylases reduces survival of drug-tolerant cancer cells. nat chem biol. 2016 jul;12(7):531-8.
CPI-455 Hydrochloride Preparation Products And Raw materials
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