MM-589 TFA salt manufacturers
- MM-589 TFA
-
- $2.00 / 1kg
-
2024-04-02
- CAS:2097887-21-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 200kg
|
| | MM-589 TFA salt Basic information |
| | MM-589 TFA salt Chemical Properties |
| storage temp. | -20°C, away from moisture | | solubility | DMSO : 25 mg/mL (36.40 mM; ultrasonic and warming and heat to 60°C) |
| | MM-589 TFA salt Usage And Synthesis |
| Biological Activity | MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interactions. MM-MM-589 TFA binds WDR5 with an IC50 of 0.90 nM. IC50 for inhibition of MLL H3K4 methyltransferase activity is 12.7 nM. | | in vitro |
MM-589 TFA (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations.
Cell Viability Assay
< table class="zh_use_1">
< tr>
|
Cell Line:
|
MV4-11 and MOLM-13 cells
|
|
Concentration:
|
0.01, 0.1, 1, 10 μM
|
|
Incubation Time:
|
4 days or 7 days
|
|
Result:
|
Potently inhibited MV4-11 and MOLM-13 cell growth with IC 50 s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC 50 of 8.6 μM.
|
| | target | IC50: 0.90 nM (WDR5), 12.7 nM (HMT) Ki: <1 nM (WDR5) |
| | MM-589 TFA salt Preparation Products And Raw materials |
|