Propargyl-PEG8-NHS ester

Propargyl-PEG8-NHS ester Suppliers list
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Products Intro: Product Name:Propargyl-PEG8-NHS ester
CAS:2182601-74-5
Purity:98% Package:Package as requetsed
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
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Products Intro: Product Name:Propargyl-PEG8-NHS ester
CAS:2182601-74-5
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Borenpharm Co., Ltd
Tel: 027-65563561 18717150066
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Products Intro: Product Name:Propargyl-PEG8-NHS ester
CAS:2182601-74-5
Purity:0.95 Package:1g; 5g
Company Name: Hangzhou Huarong Pharm Co., Ltd.
Tel: 571-86758373 +8613588754946
Email: sales@huarongpharm.com
Products Intro: Product Name:Propargyl-PEG8-NHS ester
CAS:2182601-74-5
Purity:0.99 Package:10MG,50MG,100MG,1G
Company Name: Alfa Chemistry
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Email: Info@alfa-chemistry.com
Products Intro: Product Name:Propargyl-PEG8-NHS ester
CAS:2182601-74-5

Propargyl-PEG8-NHS ester manufacturers

Propargyl-PEG8-NHS ester Basic information
Product Name:Propargyl-PEG8-NHS ester
Synonyms:Propargyl-PEG8-NHS ester;Propargyl-PEG7-CH2CH2COONHS;4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate;Propargyl-PEG7-C2-CONHS ester;Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CAS:2182601-74-5
MF:C24H39NO12
MW:533.57
EINECS:
Product Categories:
Mol File:2182601-74-5.mol
Propargyl-PEG8-NHS ester Structure
Propargyl-PEG8-NHS ester Chemical Properties
Boiling point 593.4±60.0 °C(Predicted)
density 1.21±0.1 g/cm3(Predicted)
solubility Soluble in DCM
form Viscous Liquid
color Colorless to light yellow
Safety Information
MSDS Information
Propargyl-PEG8-NHS ester Usage And Synthesis
DescriptionPropargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.
Biological ActivityPropargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Propargyl-PEG8-NHS ester Preparation Products And Raw materials
Tag:Propargyl-PEG8-NHS ester(2182601-74-5) Related Product Information
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