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| | UNIL-088 Basic information |
| Product Name: | UNIL-088 | | Synonyms: | UNIL-088;Cyclosporin A, 6-[(2S,3R,4R,6E)-3-[[N-[[1-(acetyloxy)ethoxy]carbonyl]-O-phosphono-L-seryl-N-methylglycyl]oxy]-4-methyl-2-(methylamino)-6-octenoic acid]- | | CAS: | 473545-11-8 | | MF: | C73H128N13O22P | | MW: | 1570.87 | | EINECS: | | | Product Categories: | | | Mol File: | 473545-11-8.mol |  |
| | UNIL-088 Chemical Properties |
| density | 1.108±0.06 g/cm3(Predicted) | | pka | 1.81±0.10(Predicted) |
| | UNIL-088 Usage And Synthesis |
| Description | UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is grafted via an ester function to CsA and the solubilizing group is a phosphate ion. UNIL-088 can be rapidly hydrolysed under physiological conditions, and can retain a long shelf-life in aqueous media. UNIL-088 is more stable at pH 5 than at pH 7 with conversion rate constant of 3.2 x 10(-3) and 26.0 x 10(-3)days(-1), respectively. |
| | UNIL-088 Preparation Products And Raw materials |
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