ARG--TYR--LEU--PRO-THR
| 中文名称 | ARG--TYR--LEU--PRO-THR |
|---|---|
| 中文同义词 | 化合物PROCTOLIN;2-[[1-[2-[[2-[[2-AMINO-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]AMINO]-3-(4-HYDROXYPHENYL)PROPANOYL]AMINO]-4-METHYLPENTANOYL]PYRROLIDINE-2-CARBONYL]AMINO]-3-HYDROXYBUTANOIC ACID;直肠肽;直肠肽三氟乙酸盐 |
| 英文名称 | PROCTOLIN |
| 英文同义词 | Proctolin【Periplaneta americana】;L-Arg-L-Tyr-L-Leu-L-Pro-L-Thr-OH;2-[[1-[2-[[2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoicacid;L-Threonine, L-arginyl-L-tyrosyl-L-leucyl-L-prolyl-;Proctolin,inhibit,Inhibitor;proctolin (ixodes scapularis);Proctolin TFA |
| CAS号 | 57966-42-4 |
| 分子式 | C30H48N8O8 |
| 分子量 | 648.75 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 57966-42-4.mol |
| 结构式 |  |
ARG--TYR--LEU--PRO-THR 性质
| 密度 | 1.43±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 3.28±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
Proctolin can increase the frequency of action potentials, increase the amplitude of muscle contraction, and initiate activity in quiescent systems. In the arthropods, Proctolin acts as a neuromodulator and possibly as a neurohormone. It does not appear to function as a conventional neurotransmitter. Proctolin is a pentapeptide with the mature peptide of RYLPT, and it is the first insect neuropeptide to be sequenced and chemically characterized. The first identification of a Proctolin precursor gene is CG7105 in D. melanogaster . Although a previous study showed that Proctolin is absent in B. mori , this pentapeptide is recently identified in a proteomic analysis of B. mori wings. However, the Bombyx Proctolin gene does not produce a mature peptide because cleavage sites are not present at the N-terminal and C-terminal of the RYLPT sequence, and a similar gene is observed in C. suppressalis . Therefore, a true Proctolin has been considered to be not observed in B. mori and C. suppressalis .