NIK SMI1 manufacturers
- NIK SMI1
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- $163.00 / 1mg
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2024-11-19
- CAS:1660114-31-7
- Min. Order:
- Purity: 99.99%
- Supply Ability: 10g
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| | NIK SMI1 Basic information |
| Product Name: | NIK SMI1 | | Synonyms: | NIK SMI1;(R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide;2-Pyridinecarboxamide, 6-[3-[2-[(3R)-3-hydroxy-1-methyl-2-oxo-3-pyrrolidinyl]ethynyl]phenyl]-4-methoxy-;NIK inhibitor 4f(NIK SMI1);NIK SMI1,Nuclear factor-κB,NIK SMI 1,Nuclear factor-kappaB,inhibit,Inhibitor,NF-κB,NIK SMI-1;4-methoxy-6-(3-methylphenyl)pyridine-2-carboxamide;NIK SMI1, 10 mM in DMSO | | CAS: | 1660114-31-7 | | MF: | C20H19N3O4 | | MW: | 365.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1660114-31-7.mol |  |
| | NIK SMI1 Chemical Properties |
| Boiling point | 626.7±55.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (273.69 mM) | | form | Solid | | pka | 11.14±0.20(Predicted) | | color | Off-white to pink |
| | NIK SMI1 Usage And Synthesis |
| Uses | NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor. | | Biological Activity | NIK SMI1 is an orally active, ATP site-targeting, potent and selective NF-KB-inducing kinase inhibitor (h/m NIK IC50 = 230/395 pM; hKHS1/hPKD1/hLRRK2 = 49.6/75.2/247.8 nM) th at selectively disrupts noncanonical NF-KB signaling (anti-LTβR-induced p52 nuclear translocation IC50 = 70 nM; TNFα-induced p65 RelA nuclear translocation IC50 >2 μM). SMI1 inhibits BAFF receptor- and CD40-mediated singling in cultures (human and murine B-cells) and shows in vivo efficacy in the NZB/W F1 murine experimental lupus model (6-400 mg/kg/day, b.i.d. p.o.). |
| | NIK SMI1 Preparation Products And Raw materials |
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