| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CXCR2-IN-2
CAS:1838123-21-9
Purity:95% Package:2mg;5mg;25mg
|
| Company Name: |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
|
| Tel: |
021-59167510 18117107507 |
| Email: |
vip@med-life.cn |
| Products Intro: |
Product Name:CXCR2-IN-2
CAS:1838123-21-9
Purity:>=99% Package:100mg;5mg;500mg;10mM*1mLinDMSO;200mg;10mg;50mg;25mg
|
CXCR2-IN-68 manufacturers
- CXCR2-IN-2
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- $2820.00 / 100mg
-
2024-10-28
- CAS:1838123-21-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | CXCR2-IN-68 Basic information |
| Product Name: | CXCR2-IN-68 | | Synonyms: | CXCR2-IN-68;Urea, N-[4-chloro-2-hydroxy-3-[[(3S)-tetrahydro-3-methyl-3-furanyl]sulfonyl]phenyl]-N'-[(1R)-2-methyl-2-cyclopenten-1-yl]-;CXCR2-IN-2;CXCR2IN2,CXCR2 IN 2,CXCR-2-IN-2 | | CAS: | 1838123-21-9 | | MF: | C18H23ClN2O5S | | MW: | 414.9 | | EINECS: | | | Product Categories: | | | Mol File: | 1838123-21-9.mol |  |
| | CXCR2-IN-68 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 240 mg/mL (578.45 mM; Need ultrasonic) | | form | Solid | | color | White to off-white |
| | CXCR2-IN-68 Usage And Synthesis |
| Biological Activity | CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1].
CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in rat and mouse air pouch models[1]. | | References | [1]. Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532. |
| | CXCR2-IN-68 Preparation Products And Raw materials |
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