AS-2077715

AS-2077715 Suppliers list
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Tel: 18818260767
Email: sales@chemegen.com
Products Intro: Product Name:AS-2077715
CAS:1637356-98-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
Company Name: Shanghai Yiyan Biotechnology Co. , Ltd.  
Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Products Intro: Product Name:AS-2077715
CAS:1637356-98-9
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Products Intro: Product Name:AS-2077715
CAS:1637356-98-9
Purity:70% Package:1mg;10mg;50mg
Company Name: Guangzhou Yaoguang Technology Co., Ltd.  
Tel: 13020159086
Email: yangjue@ygfuture.com
Products Intro: Product Name:AS2077715
CAS:1637356-98-9
Purity:98% Package:1G;10G;100G
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:AS-2077715
CAS:1637356-98-9
Package:50mg;10mg
AS-2077715 Basic information
Product Name:AS-2077715
Synonyms:AS-2077715;2(1H)-Pyridinone, 3-[6-(3,5-dimethylheptyl)tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)-;3-[6-(3,5-dimethylheptyl)tetrahydro-2H-pyran-2-yl]-4-hydroxy-1-methyl-5-(2,3,4,5-tetrahydroxycyclopentyl)-2(1H)-pyridinone
CAS:1637356-98-9
MF:C25H41NO7
MW:467.6
EINECS:
Product Categories:
Mol File:1637356-98-9.mol
AS-2077715 Structure
AS-2077715 Chemical Properties
Boiling point 622.9±55.0 °C(Predicted)
density 1.274±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form A solid
pka4.50±1.00(Predicted)
Safety Information
MSDS Information
AS-2077715 Usage And Synthesis
Biological ActivityAS-2077715 is a fungal metabolite and an inhibitor of fungal mitochondrial complex III (cytochrome bc1; IC50 = 80 ng/ml for T. mentagrophytes complex III).1 It is selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III, respectively). AS-2077715 inhibits ATP production in (IC50 = 0.33 μg/ml) and is fungicidal against T. mentagrophytes when used at concentrations of 1 and 10 μg/ml. In vivo, AS-2077715 (10 and 20 mg/kg) reduces the number of foot pad skin colony forming units (CFUs) in a guinea pig model of T. mentagrophytes infection.2
References1.Ohsumi, K., Watanabe, M., and Fujie, A.AS2077715 Is a selective inhibitor of fungal mitochondrial cytochrome Bc? complexJ. Antibiot. (Tokyo)67(10)713-716(2014) 2.Ohsumi, K., Murai, H., Nakamura, I., et al.Therapeutic efficacy of AS2077715 against experimental tinea pedis in guinea pigs in comparison with terbinafineJ. Antibiot. (Tokyo)67(10)717-719(2014)
AS-2077715 Preparation Products And Raw materials
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