2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)
| 中文名称 | 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) |
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| 中文同义词 | 腺苷 5'-(三磷酸四氢酯) 3'-(4-苯甲酰基苯甲酸酯) 三乙胺盐;2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C);2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐;化合物BZATP TRIETHYLAMMONIUM SALT;2′(3′)-O-(4-苯甲酰苯甲酰)腺苷5′-三磷酸 三乙铵盐;BZATP三乙铵盐;((2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-3-((4-苯甲酰基苯甲酰基)氧基)-4-羟基四氢呋喃-2-基)甲基三磷酸 三乙基铵盐(1:1) |
| 英文名称 | 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT |
| 英文同义词 | 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT;2'-3'-O-(4-benzoylbenzoyl)adenosine*5'-triphospha;2'-3'-O-(4-BENZOYLBENZOYL)ADENOSINE5'-TR IPHOSPHATE;BENZOYLBENZOIC ADENOSINE 5'-TRIPHOSPHATE;2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphatetri(triethylammonium)salt;2'(3')-o-(4-benzoylbenzoyl)adeno;Adenosine 5'-(tetrahydrogen triphosphate) 3'-(4-benzoylbenzoate) compd. with N,N-diethylethanamine;2'(3')-o-(4-benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt |
| CAS号 | 112898-15-4 |
| 分子式 | C30H39N6O15P3 |
| 分子量 | 816.58 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 112898-15-4.mol |
| 结构式 |  |
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | DMSO 中≤14 mg/ml |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 5mM) |
| InChIKey | HVOVBTNCGADRTH-WBLDMZOZSA-N |
BzATP triethylammonium salt 是一种 P2X 受体激动剂，对 P2X1，P2X2，P2X3，P2X2/3，P2X4 和 P2X7 的 pEC50 分别为 8.74，5.26，7.10，7.50， 6.19，6.31 和 5.33。BzATP triethylammonium salt 对 P2X7 受体有效，对大鼠 P2X7 和小鼠 P2X7 的EC50 分别为 3.6 μM 和 285 μM。
pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)
BzATP (10-1000 μM; 24 h) promotes the proliferation and migration of U87 and U251 glioma cells.
P2X7R protein expression is induced by BzATP (100 μM; 6-48 h) in human glioma cells.
Cell Proliferation Assay
| Cell Line: | U87 and U251 glioma cells |
| Concentration: | 5, 10, 50, 100, 500 and 1000 μM |
| Incubation Time: | 2, 6, 12, 24, 48 and 72 hours |
| Result: |
The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000 uM and 100-1000 μM, respectively.
The peak of cell proliferation of both U87 and U251 cell lines was at 100 μM. The optimal incubation time is 24 hours in both U87 and U251 cells lines. |
Western Blot Analysis
| Cell Line: | U87 and U251 glioma cells |
| Concentration: | 100 μM |
| Incubation Time: | 6-48 hours |
| Result: | Induced the upregulation of P2X7R. |
BzATP (5 mg/kg) significantly promotes P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction.
| Animal Model: | Male 2-month-old C57BL/6 mice (each weighing between 20 and 25 g) |
| Dosage: | 5 mg/kg |
| Administration: | Injected through the intraperitoneal route |
| Result: | At 48 hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively. |
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-136254 | 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) BzATP triethylammonium salt | 112898-15-4 | 5mg | 1200元 |
| 2024/11/08 | HY-136254 | 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) BzATP triethylammonium salt | 112898-15-4 | 10mg | 1900元 |