| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:c-Fms-IN-9;cFmsIN9,c Fms IN 9
CAS:1628574-50-4
Purity:98% Package:5 mg
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| | c-Fms-IN-9 Basic information |
| Product Name: | c-Fms-IN-9 | | Synonyms: | c-Fms-IN-9;cFmsIN9,c Fms IN 9;3H-1,2,4-Triazol-3-one, 5-(1,1-dimethylethyl)-1,2-dihydro-2-[6-methyl-5-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]-2-pyridinyl]- | | CAS: | 1628574-50-4 | | MF: | C21H23N7O2 | | MW: | 405.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1628574-50-4.mol |  |
| | c-Fms-IN-9 Chemical Properties |
| density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 8.97±0.20(Predicted) |
| | c-Fms-IN-9 Usage And Synthesis |
| Description | c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1, Compound Example 7. c-Fms-IN-9 inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT with IC50s of <0.01 μM and 0.1-1 μM, respectively[1].
c-FMS[1] c-Fms-IN-9 inhibits M-NFS-60, THP-1 and osteoclast cells proliferation with IC50s of 0.01-0.1 μM[1]. | | References | [1]. Gary E. L. BRANDT, et al. 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities. WO2014145023A1. |
| | c-Fms-IN-9 Preparation Products And Raw materials |
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