| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:SK33
CAS:1928724-23-5
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:3-(3,5-Bis(trifluoromethyl)phenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
CAS:1928724-23-5
Purity:98% Package:1mg;5mg;10mg;25mg;50mg;100mg Remarks:BD01296926
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| Product Name: | SK33 | | Synonyms: | SK33;Androgen Receptor,inhibit,androgen,PC3,cancer,prostate,SK 33,SK-33,Inhibitor,tissue,LNCaP,SK33,analogues,cells;Propanamide, 3-[3,5-bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-;3-(3,5-Bis(trifluoromethyl)phenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide | | CAS: | 1928724-23-5 | | MF: | C20H13F9N2O3 | | MW: | 500.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1928724-23-5.mol |  |
| Boiling point | 540.5±50.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (199.88 mM; Need ultrasonic) | | form | Solid | | pka | 12.12±0.29(Predicted) | | color | White to off-white |
| Biological Activity | SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].
In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1].
SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1]. | | References | [1]. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858. |
| | SK33 Preparation Products And Raw materials |
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