| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
|
| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:RJW100
CAS:1276664-20-0
Purity:98%+HPLC Package:10mg，100mg，500mg，1g，2g，5g，10g，More
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:RJW100
CAS:1276664-20-0
Purity:99.00% Package:1mg;5mg;10mg
|
1-Pentalenol, 5-hexyl-1,2,3,3a,6,6a-hexahydro-4-phenyl-3a-(1-phenylethenyl)-, (1R,3aR,6aR)-rel- manufacturers
- RJW100
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- $397.00 / 1mg
-
2024-11-12
- CAS:1276664-20-0
- Min. Order:
- Purity: 99.15%
- Supply Ability: 10g
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| | 1-Pentalenol, 5-hexyl-1,2,3,3a,6,6a-hexahydro-4-phenyl-3a-(1-phenylethenyl)-, (1R,3aR,6aR)-rel- Basic information |
| Product Name: | 1-Pentalenol, 5-hexyl-1,2,3,3a,6,6a-hexahydro-4-phenyl-3a-(1-phenylethenyl)-, (1R,3aR,6aR)-rel- | | Synonyms: | RJW100;1-Pentalenol, 5-hexyl-1,2,3,3a,6,6a-hexahydro-4-phenyl-3a-(1-phenylethenyl)-, (1R,3aR,6aR)-rel-;RJW100,RJW-100;RJW100, 10 mM in DMSO | | CAS: | 1276664-20-0 | | MF: | C28H34O | | MW: | 386.57 | | EINECS: | | | Product Categories: | | | Mol File: | 1276664-20-0.mol |  |
| | 1-Pentalenol, 5-hexyl-1,2,3,3a,6,6a-hexahydro-4-phenyl-3a-(1-phenylethenyl)-, (1R,3aR,6aR)-rel- Chemical Properties |
| Boiling point | 524.0±50.0 °C(Predicted) | | density | 1.064±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Oil | | pka | 14.76±0.70(Predicted) | | color | Colorless to light yellow |
| | 1-Pentalenol, 5-hexyl-1,2,3,3a,6,6a-hexahydro-4-phenyl-3a-(1-phenylethenyl)-, (1R,3aR,6aR)-rel- Usage And Synthesis |
| Biological Activity | RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter[2].
RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 μM[1].RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 μM[1].Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 μM) binding[1].RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins[2]. | | References | [1]. Richard J Whitby, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Apr 14;54(7):2266-81. [2]. Yuxia Zhang, et al. Regulation of miR-200c by nuclear receptors PPARα, LRH-1 and SHP. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):135-9. |
| | 1-Pentalenol, 5-hexyl-1,2,3,3a,6,6a-hexahydro-4-phenyl-3a-(1-phenylethenyl)-, (1R,3aR,6aR)-rel- Preparation Products And Raw materials |
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