| Company Name: |
Jinan Jiuli Biotechnology Co. , Ltd.
|
| Tel: |
15865264761 |
| Email: |
486064515@qq.com |
| Products Intro: |
Product Name:Anticancer agent 251
CAS:1648546-79-5
Purity:98% Package:500mg；1g；5g
|
| Company Name: |
ChemeGen 中国
|
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Products Intro: |
Product Name:CAY10773
CAS:1648546-79-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- manufacturers
- CAY10773
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- $1170.00 / 10mg
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2024-10-28
- CAS:1648546-79-5
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Basic information |
| | Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Chemical Properties |
| Boiling point | 547.5±50.0 °C(Predicted) | | density | 1.488±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml,DMSO: 1 mg/ml | | form | A crystalline solid | | pka | 12.87±0.70(Predicted) |
| | Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Usage And Synthesis |
| Biological Activity | CAY10773 is a derivative of the ferroptosis inducer sorafenib .1 It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50 = 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 μM) also induces autophagy with incubation times longer than eight hours. | | References | 1.Chen, J.-N., Li, T., Cheng, L., et al.Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivativesEur. J. Med. Chem.205112661(2020) |
| | Urea, N-(3,4-dichlorophenyl)-N'-[3-[(4-quinazolinylamino)methyl]phenyl]- Preparation Products And Raw materials |
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