| Company Name: |
ChemeGen 中国
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| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Products Intro: |
Product Name:RC363
CAS:2584411-86-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
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| Tel: |
4008-099-669 |
| Email: |
23419001name@qq.com |
| Products Intro: |
Product Name:RC363
CAS:2584411-86-7
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| Company Name: |
Neobioscience Co., Ltd.
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| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:RC363
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:RC363
CAS:2584411-86-7
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| Product Name: | RC363 | | Synonyms: | RC363;Phenol, 2,6-bis(1,1-dimethylethyl)-4-(2-thienylthio)-;2,6-bis(1,1-dimethylethyl)-4-(2-thienylthio)-phenol | | CAS: | 2584411-86-7 | | MF: | C18H24OS2 | | MW: | 320.51 | | EINECS: | | | Product Categories: | | | Mol File: | 2584411-86-7.mol |  |
| | RC363 Chemical Properties |
| Boiling point | 416.7±45.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): insouble,PBS (pH 7.2): insouble | | form | A crystalline solid | | pka | 10.20±0.70(Predicted) |
| | RC363 Usage And Synthesis |
| Biological Activity | RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1 It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 μM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50 = 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT22 cells when used at a concentration of 3 μM. RC363 inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells (IC50 = 173.6 nM). | | References | 1.Bueno, D.C., Canto, R.F.S., de Souza, V., et al.New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cellsMol. Neurobiol.57(8)3273-3290(2020) |
| | RC363 Preparation Products And Raw materials |
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