Company Name: |
DC Chemicals
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Tel: |
021-58447131 13564518121 |
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sales@dcchemicals.com |
Products Intro: |
Product Name:RMC-0331 CAS:2488788-52-7 Purity:98% HPLC Package:100mg,250mg,1g
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Company Name: |
Chunchuang (Wuhan) Technology Co., Ltd
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Tel: |
15342225168 |
Email: |
yutianchun2007@126.com |
Products Intro: |
Product Name:1mg;1g;10g;100g;1Kg; CAS:2488788-52-7 Purity:99.5+HPLC Package:100g/RMB 1000
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:RMC-0331 CAS:2488788-52-7 Purity:99.81% Package:1mg/RMB 1480;5mg/RMB 3730;10mg/RMB 6660
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| Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Basic information |
Product Name: | Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- | Synonyms: | Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)-;RMC-0331;RMC 0331,RMC0331;4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl]-(4-methoxytetrahydropyran-4-yl)methanone;N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-2-chloro-6-(4-methoxyoxane-4-carbonyl)-5H,6H,7H-pyrrolo[3,4-d]pyrimidin-4-amine | CAS: | 2488788-52-7 | MF: | C22H25ClF3N5O3 | MW: | 499.91 | EINECS: | | Product Categories: | | Mol File: | 2488788-52-7.mol | |
| Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Chemical Properties |
Boiling point | 679.8±55.0 °C(Predicted) | density | 1.44±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 125 mg/mL (250.05 mM; Need ultrasonic) | form | Solid | pka | 3.19±0.11(Predicted) | color | White to yellow |
| Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Usage And Synthesis |
Biological Activity | RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].
RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro[1].
RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1]. | References | [1]. Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction. |
| Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Preparation Products And Raw materials |
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