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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-

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1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Suppliers list
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
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Products Intro: Product Name:4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2509360-22-7
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing
Company Name: Daicel Chiral Technologies (China)CO.,LTD  
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Products Intro: Product Name:4-(3-Aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
CAS:2509360-22-7
Purity:95% Package:250MG;1G Remarks:209686
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
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Products Intro: Product Name:4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2509360-22-7
Purity:98+ Package:1g/
Company Name: Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD  
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Products Intro: Product Name:4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2509360-22-7
Purity:95%+ Package:1g;5g;10g,25g
Company Name: Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd  
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Products Intro: Product Name:4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS:2509360-22-7
Purity:95% Package:1g;5g
1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-
Synonyms:1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-;4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;Thalidomide-4-O-C3-NH2;4-(3-Aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;4-(3-aminopropoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS:2509360-22-7
MF:C16H17N3O5
MW:331.32
EINECS:
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Mol File:2509360-22-7.mol
1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Structure
1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Chemical Properties
Boiling point 617.9±55.0 °C(Predicted)
density 1.425±0.06 g/cm3(Predicted)
pka10.70±0.40(Predicted)
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Usage And Synthesis
UsesThalidomide-O-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
IC 50Cereblon
References[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 4-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-(2509360-22-7) Related Product Information
4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-1-Piperazinepropanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]amino]-4-oxo-Butanoic acid 4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1Hisoindol-5-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid, Thalidomide-NH-PEG2-C2-NH2 (TFA) 5-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Pentanoic acid, 5-[[2-(2,6-dioxo-3-piperidinyl)- 2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]- 5-[(8-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- 5-[(5-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 5-[(7-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, 1H-Isoindole-1,3(2H)-dione, 4-[(10-aminodecyl)oxy]-2-(2,6-dioxo-3-piperidinyl)- 1H-Isoindole-1,3(2H)-dione, 5-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)- 3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)propanoic acid 5-[(3-aminopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione, Thalidomide-O-C5-NH2 4-((8-Aminooctyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
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