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A.T.CHEMICAL
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0755-86655561 81899190 |
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Jeffreyxu@atchem.net |
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| | Isosorbide dinitrate U.S.P24,BP98 Basic information |
| | Isosorbide dinitrate U.S.P24,BP98 Chemical Properties |
| | Isosorbide dinitrate U.S.P24,BP98 Usage And Synthesis |
| General Description | Isosorbide dinitrate,1,4:3,6-dianhydro-D-glucitol dinitrate (Isordil, Sorbitrate),occurs as a white, crystalline powder. Its watersolubility is about 1 mg/mL.
Isosorbide dinitrate, as a sublingual or chewable tablet,is effective in the treatment or prophylaxis of acute anginalattacks. When it is given sublingually, the effect begins inabout 2 minutes, with a shorter duration of action thanwhen it is given orally. Oral tablets are not effective inacute anginal episodes; the onset of action ranges from 15to 30 minutes. The major route of metabolism involves denitrationto isosorbide 5-mononitrate. This metabolite has amuch longer half-life than the parent isosorbide dinitrate.As such, this particular metabolite is marketed in a tabletform that has excellent bioavailability with much less firstpassmetabolism than isosorbide dinitrate. Isosorbide ismarketed as a combination therapy with hydralazine underthe tradename BiDil specifically for African Americanswith CHF. |
| | Isosorbide dinitrate U.S.P24,BP98 Preparation Products And Raw materials |
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