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Sigma-Aldrich
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Product Name:GF 109203X
CAS:176504-36-2
Purity:>=95% Package:250μg, 1mg Remarks:B6292
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| | BISINDOLYLMALEIMIDE I HYDROCHLORIDE Basic information |
| Product Name: | BISINDOLYLMALEIMIDE I HYDROCHLORIDE | | Synonyms: | BIM 1 hydrochloride;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;GF 109203X hydrochloride >=95% | | CAS: | 176504-36-2 | | MF: | C25H25ClN4O2 | | MW: | 448.95 | | EINECS: | | | Product Categories: | | | Mol File: | 176504-36-2.mol |  |
| | BISINDOLYLMALEIMIDE I HYDROCHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL | | form | Orange-red solid | | color | Orange to red |
| WGK Germany | 3 | | HS Code | 2933998090 |
| | BISINDOLYLMALEIMIDE I HYDROCHLORIDE Usage And Synthesis |
| Description | Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM. | | Uses | GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells. | | General Description | GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent. | | Biochem/physiol Actions | Inhibitor of protein kinase C; potent inhibitor of GSK-3. |
| | BISINDOLYLMALEIMIDE I HYDROCHLORIDE Preparation Products And Raw materials |
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