| Company Name: |
Shanghai Huzhen Industrial Co., LTD
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| Tel: |
021-60345367 13916550749 |
| Email: |
sales@shzbio.com |
| Products Intro: |
Product Name:Adiponectin
Purity:> 99% Package:50ul/RMB 1098;100ul/RMB 1880;200ul/RMB 2900 Remarks:30 kDa adipocyte complement related protein; 30 kDa adipocyte complement-related protein; ACDC; ACRP 30; ACRP30; ADIPO_HUMAN; Adipocyte; Adipocyte C1q and collagen domain containin
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| Company Name: |
AntibodySystem
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| Tel: |
17762345272 18162686757 |
| Email: |
biolab-reagents@atagenix.com |
| Products Intro: |
Product Name:Adiponectin
Purity:95% SDS-PAGE Package:1mg;100ug
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| Company Name: |
ACROBiosystems
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| Tel: |
18514007688 |
| Email: |
jiaxin.zhao@acrobiosystems.com |
| Products Intro: |
Product Name:Adiponectin
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| Product Name: | Adiponectin | | Synonyms: | Adiponectin | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Adiponectin Structure]() |
| | Adiponectin Chemical Properties |
| | Adiponectin Usage And Synthesis |
| Discovery | Mouse adiponectin cDNA was cloned from mouse
3T3-L1 cells and called adipocyte complement-related
protein of 30kDa (Acrp30) in 1995.In 1996, human adiponectin
cDNA was first cloned from adipose tissues by
Matsuzawa, who called it adipose most abundant gene
transcript 1 (apM1).Adiponectin protein was identified
from human plasma in 1996. | | Tissue distribution of mRNA | In mammals, Adipoq is mainly expressed in the white
and brown adipose tissues. In fish, adipoq is expressed
in the liver, adipose tissue, muscle, and brain. | | Regulation of synthesis and release | Plasma adiponectin levels are decreased in obesity and
diabetes. Adiponectin gene expression is activated by
peroxisome proliferator-activated receptor (PPAR) γ,
C/EBPs, nuclear factor Y, sterol-regulatory-elementbinding
protein (SREBP)-1c, SIRT1, and Foxo1, whereas it is inhibited by tumor necrosis factor (TNF)-
α, IL-6, and NFATc4.Insulin and PPARγ stimulate adiponectin
secretion via the PI3K pathway. | | Clinical implications | Adiponectin improves several dysfunctions such as
insulin resistance, hyperlipidemia, hypertension, arteriosclerosis,
and nonalcoholic steatohepatitis (NASH). In
addition, the plasma adiponectin concentrations were
decreased in patients with lifestyle-related diseases and
the metabolic syndrome associated with obesity. Thus,
adiponectin has a crucial role in diabetes and other metabolic
syndromes. | | Description | Adiponectin is a cytokine produced by adipocytes and is termed an “ adipokine.” Adiponectin functions as an insulin
sensitizer. Downregulation of adiponectin receptors and low levels of adiponectin have been associated with obesity-linked
insulin resistance. Exercise and dietary changes have been shown to raise low levels of adiponectin in obese
adolescents. Additionally, sarpogrelate hydrochloride, a 5-HT2A antagonist, elevates low adiponectin levels and
normalizes other factors associated with vascular changes seen in type 2 diabetes. | | Enzyme inhibitor | This 244-residue anti-diabetic hormone (MWmonomer = 30 kDa; Symbol: Ad) is a adipocyte-derived polypeptide that regulates energy homeostasis and glucose and lipid metabolism, mainly by increasing the insulin responsiveness of susceptible cells and by stimulating the phosphorylation/activation of the 5'-AMP-activated protein kinase, or AMPK. Adiponectin circulates in human plasma mainly as a 180-kDa middle molecular weight (MMW) hexamer and a high molecular weight (HMW) multimer of approximately 360 kDa. It has four topologically distinct regions: a short signal sequence targeting the hormone for secretion; a short species-variant region; a 65-residue region resembling collagens; and a globular domain. This adipokine, which bears similarities in domain structure to the complement protein C1q, is processed into at least three homomeric complexes, trimer, hexamer, and a high-molecularweight (HMW) octadecamer. In skeletal muscle. AMPK is stimulated with globular and full-length Ad, whereas AMPK is only stimulated by fulllength Ad in liver. Ad stimulates phosphorylation of acetyl coenzyme A carboxylase (ACC), fatty-acid oxidation, glucose uptake and lactate production in myocytes, phosphorylation of ACC and reduction of molecules involved in gluconeogenesis in the liver, and reduction of glucose levels in vivo. Inhibition of AMPK activation (See Dominant Negative Mutants) blocks each of these effects, indicating that stimulation of glucose utilization and fatty-acid oxidation by Ad occurs through activation of AMPK. |
| | Adiponectin Preparation Products And Raw materials |
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