| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:SH-42
CAS:2143952-36-5
Purity:95% Package:1mg;2mg;5mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:SH-42
CAS:2143952-36-5
Purity:≥98% Package:2mg/RMB 1494
|
| Company Name: |
|
| Tel: |
4008-099-669 |
| Email: |
23419001name@qq.com |
| Products Intro: |
Product Name:SH-42
CAS:2143952-36-5
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:SH-42
CAS:2143952-36-5
|
Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- manufacturers
- SH-42
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- $214.00 / 2mg
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2024-10-28
- CAS:2143952-36-5
- Min. Order:
- Purity: ≥98%
- Supply Ability: 10g
|
| | Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- Basic information |
| Product Name: | Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- | | Synonyms: | Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)-;SH-42 | | CAS: | 2143952-36-5 | | MF: | C25H38O4 | | MW: | 402.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2143952-36-5.mol |  |
| | Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- Chemical Properties |
| Boiling point | 482.0±45.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Chloroform: 10 mg/ml | | form | A solid | | color | White to off-white |
| | Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- Usage And Synthesis |
| Biological Activity | SH-42 is an inhibitor of ?24-dehydrocholesterol reductase (DHCR24; IC50 = 4.2 nM).1 It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2 , as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2 | | References | 1.Müller, C., Hemmers, S., Bartl, N., et al.New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductaseEur. J. Med. Chem.140305-320(2017)
2.K?rner, A., Zhou, E., Müller, C., et al.Inhibition of δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolutionProc. Natl. Acad. Sci. USA116(41)20623-20634(2019) |
| | Pregn-7-ene-3,21-diol, 20-methyl-, 3-acetate 21-formate, (3β,5α,20S)- Preparation Products And Raw materials |
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