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Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-

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Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:AGI-43192
CAS:2377491-54-6
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:AGI-43192
CAS:2377491-54-6
Purity:99% Package:$350.9/5mg;$560.9/10mg;$1130.9/25mg;Bulk package Remarks:99%
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Email: 15151849396@163.com
Products Intro: Product Name:AGI-43192
CAS:2377491-54-6
Purity:95% Package:1g
Company Name: Chengdu PEIP Pharmaceutical Technology Co., LTD.  
Tel: 028-61715638 18011352545
Email: 1242335275@qq.com
Products Intro: CAS:2377491-54-6
Package:1g;2g;5g
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Email: marketing@tsbiochem.com
Products Intro: Product Name:AGI-43192;AGI 43192,AGI43192
CAS:2377491-54-6
Purity:99.6% Package:1 mg;1 mL;10 mg;100 mg;25 mg;5 mg;50 mg
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Basic information
Product Name:Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-
Synonyms:Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-;AGI-43192;AGI 43192,AGI43192;8-(4-Chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]pyrido[4,3-d]pyrimidin-7(6H)-one
CAS:2377491-54-6
MF:C23H16ClF3N6O
MW:484.86
EINECS:
Product Categories:
Mol File:2377491-54-6.mol
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Structure
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Chemical Properties
Boiling point 601.1±65.0 °C(Predicted)
density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 83.33 mg/mL (171.86 mM; ultrasonic and warming and heat to 60°C)
pka6.69±0.20(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Usage And Synthesis
Biological ActivityAGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease[1].
References[1]. Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615.
Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]- Preparation Products And Raw materials
Tag:Pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-(2377491-54-6) Related Product Information