| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:CSF1R-IN-3
CAS:2760584-90-3
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:CSF1R-IN-3
CAS:2760584-90-3
Purity:98% Package:25 mg；50 mg
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| Company Name: |
RD International Technology Co., Limited
|
| Tel: |
18024082417 |
| Email: |
market@ubiochem.com |
| Products Intro: |
Product Name:CSF1R-IN-3
CAS:2760584-90-3
Purity:5mg;10mg;50mg;100mg;250mg;500mg;1g Package:5mg;10mg;50mg;100mg;250mg;500mg;1g
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| | 1-Piperazineacetamide, N-[5-[(Z)-[6-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-4-methyl- Basic information |
| | 1-Piperazineacetamide, N-[5-[(Z)-[6-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-4-methyl- Chemical Properties |
| Boiling point | 723.0±60.0 °C(Predicted) | | density | 1.334±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 12.62±0.70(Predicted) | | color | Yellow to orange |
| | 1-Piperazineacetamide, N-[5-[(Z)-[6-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-4-methyl- Usage And Synthesis |
| Biological Activity | CSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity[1]. | | References | [1]. Lv Q, et al. Discovery of (Z)-1-(3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-3-(isoxazol-3-yl)urea Derivatives as Novel and Orally Highly Effective CSF-1R Inhibitors for Potential Colorectal Cancer Immunotherapy. J Med Chem. 2021;64(23):17184-17208. |
| | 1-Piperazineacetamide, N-[5-[(Z)-[6-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-4-methyl- Preparation Products And Raw materials |
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