3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE
中文名称 | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE |
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中文同义词 | 化合物 T22902 |
英文名称 | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE |
英文同义词 | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE;L-733,060 HYDROCHLORIDE;L-733,061 HYDROCHLORIDE;060 hydrochloride;L-733;L733060 hydrochloride,L 733060 hydrochloride |
CAS号 | 148687-76-7 |
分子式 | C20H20ClF6NO |
分子量 | 439.82 |
EINECS号 | |
相关类别 | |
Mol文件 | 148687-76-7.mol |
结构式 | ![]() |
3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE 性质
储存条件 | 2-8°C |
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溶解度 | 二甲基亚砜:>10 mg/mL |
形态 | 固体 |
颜色 | 白色 |
水溶解性 | Soluble to 50 mM in water with gentle warming |
NK1
|
L-733060 (30-300 nM) inhibits the [Ca
2+
]
i
mobilisation caused by substance P (100 nM) in a concentration-dependent manner in human tachykinin NK
1
receptor-transfected CHO cells.
L-733060 (2.5-20 μM; 48 and or 96 h) results in a concentration-dependent cytotoxicity in COLO 858 cells.
L-733060 (10-30 μM; 24 and 48 h) inhibits MEL H0 cells proliferation with IC
50
s of 27.5 μM and 18.9 μM at 24 h and 48 h, respectively.
L-733060 (20-50 μM; and or 72 h) inhibits COLO 679 cells growth with IC
50
s of 33.8 μM and 31.5 μM at 30 h and 72 h, respectively.
Cell Proliferation Assay
Cell Line: | COLO 858 cells |
Concentration: | 2.5, 5, 10, 20 μM |
Incubation Time: | 0, 48, 96 h |
Result: | Inhibited cells growth with IC 50 s of 8.7 μM and 7.1 μM at 48 h and 96 h, respectively. |
L-733060 (10-1000 μg/kg; i.v.) inhibits electrically stimulated plasma extravasation in dura mater of rats.
L-733060 (300-3000 μg/kg; i.v.) has no significant hypotensive or bradycardic effects are observed at doses of <3000 μg/kg in conscious or anaesthetised rats.
Animal Model: | Male Sprague-Dawley rats (200 g) with electrical stimulation of the trigeminal ganglion |
Dosage: | 10, 100, 1000 mg/kg |
Administration: | I.v. injection |
Result: | Produced a significant dose-related inhibition of plasma extravasation with an ID 50 of 212±19 μg/kg. |
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
提供商 | 语言 |
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英文
|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-14406A | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE L-733060 hydrochloride | 148687-76-7 | 1 mg | 2600元 |