3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE
| 中文名称 | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE |
|---|---|
| 中文同义词 | 化合物 T22902 |
| 英文名称 | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE |
| 英文同义词 | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE;L-733,060 HYDROCHLORIDE;L-733,061 HYDROCHLORIDE;060 hydrochloride;L-733;L733060 hydrochloride,L 733060 hydrochloride |
| CAS号 | 148687-76-7 |
| 分子式 | C20H20ClF6NO |
| 分子量 | 439.82 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 148687-76-7.mol |
| 结构式 | ![3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE 结构式](CAS/GIF/148687-76-7.gif) |
3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 二甲基亚砜：>10 mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 50 mM in water with gentle warming |
|
NK1
|
L-733060 (30-300 nM) inhibits the [Ca
2+
]
i
mobilisation caused by substance P (100 nM) in a concentration-dependent manner in human tachykinin NK
1
receptor-transfected CHO cells.
L-733060 (2.5-20 μM; 48 and or 96 h) results in a concentration-dependent cytotoxicity in COLO 858 cells.
L-733060 (10-30 μM; 24 and 48 h) inhibits MEL H0 cells proliferation with IC
50
s of 27.5 μM and 18.9 μM at 24 h and 48 h, respectively.
L-733060 (20-50 μM; and or 72 h) inhibits COLO 679 cells growth with IC
50
s of 33.8 μM and 31.5 μM at 30 h and 72 h, respectively.
Cell Proliferation Assay
| Cell Line: | COLO 858 cells |
| Concentration: | 2.5, 5, 10, 20 μM |
| Incubation Time: | 0, 48, 96 h |
| Result: | Inhibited cells growth with IC 50 s of 8.7 μM and 7.1 μM at 48 h and 96 h, respectively. |
L-733060 (10-1000 μg/kg; i.v.) inhibits electrically stimulated plasma extravasation in dura mater of rats.
L-733060 (300-3000 μg/kg; i.v.) has no significant hypotensive or bradycardic effects are observed at doses of <3000 μg/kg in conscious or anaesthetised rats.
| Animal Model: | Male Sprague-Dawley rats (200 g) with electrical stimulation of the trigeminal ganglion |
| Dosage: | 10, 100, 1000 mg/kg |
| Administration: | I.v. injection |
| Result: | Produced a significant dose-related inhibition of plasma extravasation with an ID 50 of 212±19 μg/kg. |
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| 提供商 | 语言 |
|---|---|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-14406A | 3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE L-733060 hydrochloride | 148687-76-7 | 1 mg | 2600元 |