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Product Name:A 33
CAS:915082-52-9
Purity:98% Package:1G;10G;100G Remarks:A 33 is a potent and selective PDE4B inhibitor (IC50 = 15 nM) that exhibits >100-fold selectivity for PDE4B over 4D.
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| Product Name: | A 33 | | Synonyms: | A-33;Benzeneacetic acid, 4-[[2-(5-chloro-2-thienyl)-5-ethyl-6-methyl-4-pyrimidinyl]amino]-;PDE4B-IN-2 | | CAS: | 915082-52-9 | | MF: | C19H18ClN3O2S | | MW: | 387.88 | | EINECS: | | | Product Categories: | | | Mol File: | 915082-52-9.mol |  |
| storage temp. | Store at -20°C | | solubility | 38.7mg/ml in DMSO | | form | Solid | | color | White to off-white |
| Biochem/physiol Actions | A-33 (A33) is a potent and selective catalytic site-targeting PDE4B inhibitor (IC50 = 15 nM/PDE4B vs. 1.7 μM/PDE4D) that effectively prevents PDE4B-medicated cellular cAMP hydrolysis (150%/320% increased cAMP level with 100 nM/1 μM A-33 pre-treament in murine hippocampal HT-22 cells following 10 nM isoproterenol stimulation) in vitro and inhibits LPS-induced TNF-α production in mice in vivo (ID50 = 14 mg/kg p.o.). When administered via intraperitoneal injection, A-33 improves cognitive function in a rat model of traumatic brain injury (0.3 mg/kg i.p.) and exhibits antidepressant property in mice (0.3-1 mg/kg i.p.) in vivo. | | storage | Store at -20°C |
| | A 33 Preparation Products And Raw materials |
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