| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(diMethyl)silyl]oxy}-2,6,10-triMethyl-undeca-1,5-dienyl]-2-Methyl-1,3-thiazole
CAS:210690-85-0
Package:2.5g,250Mg
|
| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-BIS-([TERT-BUTYL(DIMETHYL)SILYL]OXY)-2,6,10-TRIMETHYL-UNDECA-1,5-DIENYL]-2-METHYL-1,3-THIAZOLE
CAS:210690-85-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
Chemsky（shanghai）International Co.,Ltd.
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(diMethyl)silyl]oxy}-2,6,10-triMethyl-undeca-1,5-dienyl]-2-Methyl-1,3-thiazole
CAS:210690-85-0
Purity:98%
|
| Company Name: |
S.Z. PhyStandard Bio-Tech. Co., Ltd.
|
| Tel: |
0755-83725681-603 |
| Email: |
|
| Products Intro: |
Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(diMethyl)silyl]oxy}-2,6,10-triMethyl-undeca-1,5-dienyl]-2-Methyl-1,3-thiazole
CAS:210690-85-0
Package:Mg Remarks:TRC
|
| Company Name: |
Shenzhen Polymeri Biochemical Technology Co., Ltd.
|
| Tel: |
+86-400-002-6226 +86-13028896684; |
| Email: |
sales@rrkchem.com |
| Products Intro: |
Product Name:4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(diMethyl)silyl]oxy}-2,6,10-triMethyl-undeca-1,5-dienyl]-2-Methyl-1,3-thiazole
CAS:210690-85-0
|
|
| | 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole Basic information |
| Product Name: | 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole | | Synonyms: | 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole;4-[(1E,3S,5Z,10S)-3,11-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]-2,6,10-triMethyl-1,5-undecadien-1-yl]-2-Methyl-thiazole;Thiazole, 4-[(1E,3S,5Z,10S)-3,11-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2,6,10-trimethyl-1,5-undecadien-1-yl]-2-methyl-;Paclitaxel Impurity 75 | | CAS: | 210690-85-0 | | MF: | C30H57NO2SSi2 | | MW: | 552.02 | | EINECS: | | | Product Categories: | Chiral Reagents | | Mol File: | 210690-85-0.mol | ![4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole Structure](CAS2/GIF/210690-85-0.gif) |
| | 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole Chemical Properties |
| Boiling point | 550.1±50.0 °C(Predicted) | | density | 0.939±0.06 g/cm3(Predicted) | | solubility | Chloroform, Dichloromethane, Ethanol, Ethyl Acetate, Methanol, Toluene | | form | Oil | | pka | 2.73±0.10(Predicted) | | color | Colourless |
| | 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole Usage And Synthesis |
| Chemical Properties | Colourless Oil | | Uses | An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
| | 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole Preparation Products And Raw materials |
|