氯苯氨啶
中文名称 | 氯苯氨啶 |
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中文同义词 | 5-(3,4-二氯苯基)-6-甲基嘧啶-2,4-二胺;氯苯氨啶 |
英文名称 | Metoprine |
英文同义词 | 5-(3,4-dichlorophenyl)-6-MethylpyriMidine-2,4-diaMine;5-(3,4-Dichlorophenyl)-6-Methyl-2,4-pyriMidinediaMine;BW 197U;NSC 7364;SK 5265;Metoprine;methodichlorophen;2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-METHYLPYRIMIDINE |
CAS号 | 7761-45-7 |
分子式 | C11H10Cl2N4 |
分子量 | 269.13 |
EINECS号 | |
相关类别 | Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals |
Mol文件 | 7761-45-7.mol |
结构式 |
氯苯氨啶 性质
熔点 | 275-276℃ |
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沸点 | 418.42°C (rough estimate) |
密度 | 1.447 |
折射率 | 1.6300 (estimate) |
储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
溶解度 | DMSO(略微加热)、甲醇(略微加热、超声处理) |
形态 | 固体 |
酸度系数(pKa) | 6.80±0.10(Predicted) |
颜色 | 灰白色至浅黄色 |
稳定性 | 吸湿性 |
Metoprine (BW 197U) 是一种有效的组胺 N-甲基转移酶 (HMT) 抑制剂。Metoprine 是一种二氨基嘧啶衍生物,可以透过血脑屏障,并通过抑制 HMT 增加脑组胺水平。Metoprine 是一种抗叶酸 (antifolate) 和抗肿瘤药。
Metoprine (BW 197U; 2-10 mg/kg; IP) ameliorates the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner.
Intraperitoneal administration of Metoprine produces various behavioral effects, including decreases in food intake and increases in water consumption.
Animal Model: | Male Sprague-dawley rats (200-280g) |
Dosage: | 2, 5, 10 mg/kg |
Administration: | IP |
Result: | Ameliorated the memory deficits induced by nucleus basalis magnocellularis (NBM) lesions in a dose-dependent manner and significanty prolonged transfer latency at a high dose of 10 mg/kg. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-129441 | Metoprine | 5 mg | 687元 | |
2024/04/30 | HY-129441 | 氯苯氨啶 Metoprine | 7761-45-7 | 10mg | 1100元 |