| Company Name: |
ShangHai Biochempartner Co.,Ltd
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| Tel: |
17754423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:c-di-AMP disodium
CAS:2734909-87-4
Purity:98% HPLC LCMS Package:100mg;500mg;1g
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| Company Name: |
Hefei Stongbio Co.,Ltd.
|
| Tel: |
15555170917 |
| Email: |
sales@stongbio.com |
| Products Intro: |
CAS:2734909-87-4
Purity:>=95% Package:1g;10g;100g
|
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| | c-di-AMP disodium Basic information |
| | c-di-AMP disodium Chemical Properties |
| storage temp. | Store at -80°C, protect from light, stored under nitrogen | | solubility | DMSO : 270 mg/mL (384.41 mM; Need ultrasonic) | | form | A crystalline solid | | color | White to off-white | | Water Solubility | Water : ≥ 50 mg/mL (71.19 mM) |
| | c-di-AMP disodium Usage And Synthesis |
| Biological Activity | c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].
c-di-AMP (Cyclic diadenylate) sodium signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP sodium is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].c-di-AMP sodium combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4]. | | storage | Store at -20°C | | References | [1]. Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8). [2]. Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519. [3]. Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31. [4]. Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824. |
| | c-di-AMP disodium Preparation Products And Raw materials |
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