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TargetMol Chemicals Inc.
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Product Name:sEH/AChE-IN-3
CAS:2490589-11-0
Package:100mg/RMB 21500;25mg/RMB 12800;50mg/RMB 16800
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Urea, N-[1-[5-[[(7S,11S)-3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl]amino]-1-oxopentyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- manufacturers
- sEH/AChE-IN-3
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- $3100.00 / 100mg
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2024-10-28
- CAS:2490589-11-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Urea, N-[1-[5-[[(7S,11S)-3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl]amino]-1-oxopentyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- Basic information |
| Product Name: | Urea, N-[1-[5-[[(7S,11S)-3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl]amino]-1-oxopentyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- | | Synonyms: | Urea, N-[1-[5-[[(7S,11S)-3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl]amino]-1-oxopentyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-;sEH/AChE-IN-3 | | CAS: | 2490589-11-0 | | MF: | C35H39ClF3N5O3 | | MW: | 670.16 | | EINECS: | | | Product Categories: | | | Mol File: | 2490589-11-0.mol | ![Urea, N-[1-[5-[[(7S,11S)-3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl]amino]-1-oxopentyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- Structure](CAS/20210305/GIF/2490589-11-0.gif) |
| | Urea, N-[1-[5-[[(7S,11S)-3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl]amino]-1-oxopentyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- Chemical Properties |
| Boiling point | 757.5±60.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | pka | 13.11±0.20(Predicted) |
| | Urea, N-[1-[5-[[(7S,11S)-3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl]amino]-1-oxopentyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- Usage And Synthesis |
| Uses | sEH/AChE-IN-3 (compound (?)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively[1]. | | References | [1] Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925. DOI:10.1021/acs.jmedchem.1c02150 |
| | Urea, N-[1-[5-[[(7S,11S)-3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocycloocta[b]quinolin-12-yl]amino]-1-oxopentyl]-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]- Preparation Products And Raw materials |
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